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Arsphenamine was first synthesized in 1907 in paul ehrlich's lab by alfred bertheim. the antisyphilitic activity of this compound was discovered by sahachiro hata in 1909, during a survey of hundreds of newly synthesized organic arsenical compounds. ehrlich had theorized that by screening many compounds, a drug could be discovered that would have anti-microbial activity …

Patients receiving the fixed combination of glyburide and metformin had greater reductions in hba 1c and fasting plasma glucose concentrations than those receiving glyburide, metformin, or placebo; at the end of the study, strict glycemic control (e.g., hba 1c values less than 7%) was achieved in 59.9, 50.4, 66.4, or 71.7% of patients receiving ...

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